Neurofibromatosis type 1 and subungual glomus tumors: A noteworthy association
نویسندگان
چکیده
منابع مشابه
Glomus tumors in neurofibromatosis type 1: genetic, functional, and clinical evidence of a novel association.
Neurofibromatosis type 1 (NF1) is a common disorder that arises secondary to mutations in the tumor suppressor gene NF1. Glomus tumors are small, benign but painful tumors that originate from the glomus body, a thermoregulatory shunt concentrated in the fingers and toes. We report 11 individuals with NF1 who harbored 20 glomus tumors of the fingers and 1 in the toe; 5 individuals had multiple g...
متن کاملGlomus tumors in individuals with neurofibromatosis type 1.
BACKGROUND Glomus tumors have recently been reported in individuals with the neurofibromatosis type 1 (NF1) cancer disposition syndrome. We compare the clinical and molecular features of these painful hamartomas in a series of sporadic and NF1-associated cases. OBJECTIVE We sought to evaluate the association of NF1 with glomus tumors and to compare NF1-associated glomus tumors with sporadic g...
متن کاملGlomus Tumors and Neurofibromatosis: A Newly Recognized Association
BACKGROUND Glomus tumors are painful benign tumors arising from the neuromyoarterial elements of the glomus body, typically in a subungual location. Historically, glomus tumors have been considered isolated or sporadic, not typically associated with other disease processes. Over the last few years, however, multiple case reports, a molecular genetics study, and an epidemiologic study have confi...
متن کاملTreatment of subungual glomus tumor.
We report four cases of chronic obscure pain in the finger tips. High-resolution magnetic resonance imaging (HR-MRI) findings helped diagnose the existence of a mass at the subungual area and all patients were treated with excision and biopsy. The pathological diagnosis was glomus tumor. HR-MRI is useful in the diagnosis of patients with subungual glomus tumor.
متن کاملMultiple glomus tumors and segmental neurofibromatosis: there are no coincidences.
Segmental neurofibromatosis is a rare subtype of neurofibromatosis type 1 (NF1). Glomus tumors are uncommon benign tumors. The authors report the association between these two rare conditions, not yet reported.
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ژورنال
عنوان ژورنال: Journal of the American Academy of Dermatology
سال: 2021
ISSN: 0190-9622
DOI: 10.1016/j.jaad.2020.09.041